INDUCTION OF HEPATIC CARISOPRODOL-METABOLIZING ENZYME BY PRETREATMENT WITH SOME NEUROPSYCHOTROPIC DRUGS IN RATS
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منابع مشابه
Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats.
Racemic fenvaleric acid [2-(4-chlorophenyl)-3-methyl-butanoic acid], the principal metabolite of fenvalerate, was administrated orally at 0.75, 1.5, and 3.0 mmol/kg body weight/day to Fisher-344 male rats for 7 days. Both pure enantiomers of fenvaleric acid were administered at 1.5 mmol/kg body weight/day; the clofibric acid at the same concentration was used as a positive control. Hepatic enzy...
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Bock, K. W., Bock-Hennig, B. S., Lilienblum, W. & Volp, R. (1981) Chem.-Biol. Interact. 36, 167-177 Bock, K. W., Lilienblum, W., Pfeil, H. & Eriksson, L. C. (1982) Cancer Res. 42, 3747-3752 Bock, K. W., Burchell, B., Dutton, G. J., Hanninen, O., Mulder, G. J., Owens, I. S., Siest, G. & Tephly, T. R. (1983) Biochem. Pharmacol. 32, 953-955 Bock, K. W., Bock-Hennig, B. S., Fischer, G., Lilienblum,...
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1. Pretreatment of female rats with (-)-emetine or (±)-2,3-dehydroemetine (at 18,umol/kg body wt. for 24h) prolongs the hexobarbital-induced sleeping-time of the treated animals. 2. This effect is not observed on pretreating animals with other compounds closely related to (-)-emetine, such as (-)-isoemetine or (+)-O-methylpsychotrine. 3. Liver microsomal drug-metabolizing enzyme activity in vit...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1962
ISSN: 0021-5198
DOI: 10.1254/jjp.11.31